Lung in both men and women. It is

Lung cancer has become the one of the
prominent threats to
world  healthcare, with death rate of one out of four
deaths in both men and women. It is among one of cause of cancer related deaths
all over the world 1. Golbally lung cancer 
accounts for about 13 % of  new
cancer cases and 19 % fatality . In India, lung cancer accounts for 6.9 %
of  new 
cases and 9.3%  deaths in both
sexes, it is the commonest cancer and cause of cancer related mortality in
men,  and second most in women after
breast and ovarian carcinoma 2. Depending on tumour size and stages of lung
cancer several therapeutic regimens are available to treat lung cancer. Yet
conventional treatments like chemotherapy and radiation therapy are associated
with several adverse effects on the human system. Even though  of the progress in development  of several anticancer drugs, chemoresistance
is still major  obstacle that results
in the failure   of treatment3.
Multiple factors are involved in development of chemoresistance such as
inactivation of chemotherapy drug, alteration in tumor suppressor gene, anti
and pro apoptotic proteins. Understanding the moleculer role of tumor encoded
gene in development of drug resistance has great significance in development of
novel therapeutic target and also improve diagnosis4.

Tissue transglutaminase 2 (TG2)  is one of ubiquitously expressed protein
among 7 members of Tissue TG family. It is known to be involved in tumor
metastasis 5. It is distributed among major cell types and tissues and plays
a significant role in several biological processes. It take part in  post-translation modification  transamidase activity it is involved in
GTPase, ATPase, protein kinase, protein disulfide, and isomerase activity 6.

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TG2 levels leads to different pathological disorders such as
Alzheimer’s, Parkinson’s disease, multiple sclerosis, celiac  along with tumour development while Over
expression of TG2is associated with malignant effects leading to tumorigenesis,
invasion, cell differentiation, and failure in apoptosis 7.As a consequence,
TG2 is known to have a significant impact in lung carcinoma, especially towards
non-small cell lung carcinoma 8. Targeting TG2 protein may be valuable in
identifying potential inhibitors against lung cancer. Numerous natural
compounds have been reported to have many biological activities as
antibacterial, antiviral and anti-cancer 9. Natural products and their
derivatives mimic over 50% of all the products that are being used. In the
present study an attempt is made in silico investigation of natural inhibitors
against TG2 from plant origin. The hit compounds obtained in this study could
play an important role in designing personalized therapy against lung cancer